Information détaillée du papier
| Titre de l’article | The role of sleep in adolescent brain development: Evidence from a longitudinal MRI study |
|---|---|
| Code d’article | P05 |
| Auteurs | |
| Forme de présentation | Poster |
| Domaines thématiques |
|
| Résumé (Abstract) |
Introduction: The adolescent brain undergoes significant maturation. Both genetic and environmental factors drive the changes to white and grey matter volumes that typically occur during this transitional period. One such environmental factor is sleep, with prior studies suggesting that variables like sleep duration and regularity are linked to regional grey matter volumes. However, the associations between sleep and adolescent brain development have mostly been studied cross-sectionally using self-reported sleep. Therefore, this study aims to investigate the longitudinal links between grey matter volumes and objectively measured sleep. Methods: The sample consisted of thirty-nine adolescents aged 10 to 14 years (mean age = 12.72 (± 1.0) years, 16 females). At baseline and at 6 months follow-up, grey matter volumes were assessed by means of MRI. Sleep duration, efficiency, regularity and midpoint were derived from actigraphy data that were collected continuously in the intervening six months. Each of the sleep variables was included as a moderator variable potentially influencing the association between baseline and follow-up brain volumes. Pubertal status and gender served as covariates. Brain regions of interest were defined based on prior evidence on sleep and brain volumes in adolescence. Results: Sleep duration and efficiency on school and free days and sleep midpoint on free days moderated the changes in brain volumes in several regions, including the Thalamus, Precuneus, Lateral Orbitofrontal Cortex, and the Amygdala (.11 ≤ ΔR2 ≥ .50, .001 < p < .019). Analysis of conditional effects at different values of the moderator revealed that for those subjects with sleep duration (school/free days) and sleep efficiency (schooldays) below one standard deviation of the mean, fewer changes in brain volume from baseline to follow-up were occurring. For those with sleep midpoint (weekend) above one standard deviation of the mean, Thalamus volumes at baseline and follow-up were closely associated, indicating stability of thalamic volumes for later midpoint. For the Amygdala, a reverse pattern was found. Conclusion: Results of moderation analyses showed that, often, less change in volume over time was observed for sleep values below the mean. More volume change was apparent in areas of the data that might be an indication of healthy sleep (e.g., above mean sleep duration), which may suggest that adequate sleep might beneficially influence brain maturation. |